2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers
  5. PROTAC Linkers Isoform

PROTAC Linkers

 

PROTAC Linkers Related Products (206):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W021401
    Amino-PEG3-C2-Azido 134179-38-7 99.67%
    Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645). Amino-PEG3-C2-Azido is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Amino-PEG3-C2-Azido
  • HY-W008574A
    TGN-020 sodium 1313731-99-5 99.99%
    TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats.
    TGN-020 sodium
  • HY-W007803
    Boc-NH-C4-Br 164365-88-2 ≥98.0%
    Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-C4-Br
  • HY-108374
    4-Azidobutylamine 88192-20-5 ≥98.0%
    4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    4-Azidobutylamine
  • HY-130653
    Azido-PEG4-C2-acid 1257063-35-6 ≥98.0%
    Azido-PEG4-C2-acid a PEG-based PROTAC linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-C2-acid
  • HY-69260
    tert-Butyl 4-formylpiperidine-1-carboxylate 137076-22-3 99.54%
    tert-Butyl 4-formylpiperidine-1-carboxylate is the linker of PROTAC BRM/BRG1 degrader-3 (HY-168251).
    tert-Butyl 4-formylpiperidine-1-carboxylate
  • HY-43048
    2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid 2231744-57-1
    2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid is a PROTACT linker in PROTAC SMARCA2/4-degrader-34 (HY-169279).
    2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid
  • HY-W248248
    tert-Butyl 9-aminononanoate 134857-22-0 ≥98.0%
    tert-Butyl 9-aminononanoate is a PROTAC linker. tert-Butyl 9-aminononanoate can be used in synthesis PROTAC sEH-degrader-1 (HY-159494).
    tert-Butyl 9-aminononanoate
  • HY-W015088
    Amino-PEG3-C2-Amine 929-75-9 99.32%
    Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG3-C2-Amine
  • HY-W008296
    NH2-C6-NH-Boc 51857-17-1 99.61%
    NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC.
    NH2-C6-NH-Boc
  • HY-W092043
    TLR4-IN-C34-C2-COOH 1159408-54-4
    TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
    TLR4-IN-C34-C2-COOH
  • HY-151716
    Halo-DBCO 1808119-16-5 98.00%
    Halo-DBCO is a click chemistry reagent containing dibenzocyclooctyne (DBCO). Halo-DBCO can be used as a ligand to react with HaloTag to form covalent HaloTag ligand couples.
    Halo-DBCO
  • HY-130659
    Amino-PEG8-amine 82209-36-7 ≥98.0%
    Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG8-amine
  • HY-30756
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate 236406-55-6 99.89%
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is a PROTAC linker. tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is the linker of PROTAC ER Degrader-12 (HY-160264) and PROTAC AR Degrader-9 (HY-170332).
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate
  • HY-W003696
    tert-Butyl 5-bromoisoindoline-2-carboxylate 201940-08-1 98.89%
    tert-Butyl 5-bromoisoindoline-2-carboxylate is a PROTAC Linker. tert-Butyl 5-bromoisoindoline-2-carboxylate can be used in synthesis PTOTAC HSD17B13 degrader 1 (HY-159651).
    tert-Butyl 5-bromoisoindoline-2-carboxylate
  • HY-W007700
    8-Bromooctanoic acid 17696-11-6 99.89%
    8-Bromooctanoic acid is a PROTAC linker, and can be used for synthesis of PROTAC CYP1B1 degrader-2 (HY-158429).
    8-Bromooctanoic acid
  • HY-136158A
    6-Maleimidocaproic acid sulfo-NHS sodium 215312-86-0 98.91%
    6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    6-Maleimidocaproic acid sulfo-NHS sodium
  • HY-130871A
    HS-PEG3-CH2CH2NH2 hydrochloride
    HS-PEG3-CH2CH2NH2 hydrochloride (Thiol-PEG3-amine hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HS-PEG3-CH2CH2NH2 hydrochloride
  • HY-140656A
    Biotin-PEG-Biotin 194920-55-3
    Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG-Biotin
  • HY-22391
    tert-Butyl (7-aminoheptyl)carbamate 99733-18-3
    tert-Butyl (7-aminoheptyl)carbamate (tert-Butyl 2,8-diaminooctanoate) is a PROTAC linker. tert-Butyl (7-aminoheptyl)carbamate can be used to synthesis CPD-10 (HY-168660).
    tert-Butyl (7-aminoheptyl)carbamate